I just started using fluid.app .  It’s a small app for mac that makes Web-Kit based SSB’s (Site Specific Browser).  In other words it makes a cocoa mac app for your website based on the same great technology of safari.  I used it to create a little app for the wordpress admin for the website.  This functions perfectly, and works great, because while i love word press’s advanced admin and posting features: i hate that they are confined to the web browser (and don’t really want marsedit).  So know i have the desktop blogging app i always wanted.  The apps are real cocoa apps with scripting and automator support, and can be handed around just like normal apps if you want.  I know some people who’ve used fluid to create desktop iterations of google reader, and before i tried fluid, a friend of mine sent me one, and i didn’t even know it was built with fluid, it even had a custom icon (which fluid supports)